Human DKK3 (Dickkopf Related Protein 3) ELISA Kit

Dickkopf-Related Protein 3; Dickkopf-3; Dkk-3; Hdkk-3

Uniprot ID: S10A9_HUMAN ; Gene ID: 27122

Tissue Specificity: Highest expression in heart, brain, and spinal cord.

Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.