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Target Information
Target NameDickkopf-Related Protein 1; Dickkopf-1; Dkk-1; Hdkk-1; SkDatabase LinksUniprot ID: LYAM1_HUMAN ; Reactome: R-HSA-201681 ; Gene ID: 22943About TargetTissue Specificity: Placenta.
Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity.
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