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Target Information
Target NameBeta-Defensin 1; Bd-1; Hbd-1; Defensin - Beta 1Database LinksUniprot ID: SEM7A_HUMAN ; Reactome: R-HSA-1461957 ; Gene ID: 1672About TargetTissue Specificity: Blood plasma. Sperm. Highly expressed in the lower head and midpiece of sperm. Significantly reduced levels found in the sperms of asthenozoospermia and leukocytospermia patients (at protein level).
Function: Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.
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