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Overview
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Target Information
Target NameCathepsin D Cleaved Into - Cathepsin D Light Chain - Cathepsin D Heavy ChainDatabase LinksUniprot ID: PRELP_HUMAN ; Reactome: R-HSA-1442490 ; Gene ID: 1509About TargetTissue Specificity: Expressed in the aorta extracellular space (at protein level). Expressed in liver (at protein level).
Function: Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
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Overview