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Target Information
Target NameCathepsin K; Cathepsin O; Cathepsin O2; Cathepsin XDatabase LinksUniprot ID: PROC_HUMAN ; Reactome: R-HSA-1442490 ; Gene ID: 1513About TargetTissue Specificity: Predominantly expressed in osteoclasts (bones). Expressed in thyroid epithelial cells.
Function: Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen.
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