Human CLDN6-Strep full length protein-synthetic nanodisc

Human CLDN6-Strep full length protein-synthetic nanodisc

Catalog Number:
P001561649DIM
Mfr. No.:
FLP120008
Price:
$911
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      • Overview

        • Target: CLDN6
          Tag: C-Flag&Strep Tag
          Synonyms: Claudin 6, Claudin-6, Skullin, Claudin6
          Protein Families: Transmembrane
          Protein Pathways: Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction

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          Background

          Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.

      • Properties
        • Type
          Synthetic Nanodiscs
          Conjugate
          Unconjugated
          Formulation
          Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments.
          Storage
          Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
          Molecular Weight
          The human full length CLDN6-Strep Protein has a MW of 23.3 kDa
          Expression system
          HEK293

          More Information

          UniProt
          P56747

          * For research use only.

    MSDS

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