Human CLDN18.2 full length protein-synthetic nanodisc

Human CLDN18.2 full length protein-synthetic nanodisc

Catalog Number:
P001561712DIM
Mfr. No.:
FLP100014
Price:
$1,013
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      • Overview

        • Target: CLDN18.2
          Tag: C-Flag Tag
          Synonyms: Claudin 18.2
          Protein Families: Transmembrane
          Protein Pathways: Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction

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          Background

          The protein encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010]

      • Properties
        • Type
          Synthetic Nanodiscs
          Conjugate
          Unconjugated
          Formulation
          Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments.
          Storage
          Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
          Molecular Weight
          The human full length CLDN18.2 Protein has a MW of 27.5 kDa
          Expression system
          HEK293

          More Information

          UniProt
          P56856-2

          * For research use only.

    MSDS

    Documents

    Datasheet

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