Human Brain Derived Neurotrophic Factor (AF)

Human Brain Derived Neurotrophic Factor (AF)

Catalog Number:
P001412006ABE
Mfr. No.:
Abe32-12014
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      • Overview
        • Predicted MW: Noncovalent Homodimer, 13.6/27.3 kDa (120/240 aa). Brain-derived neurotrophic factor (BDNF) is a nerve growth factor that binds two receptors, the low-affinity nerve growth factor receptor (LNGFR) and the tropomyosin receptor kinase B (TrkB), to support neuron growth and survival. BDNF expression in the hippocampus is essential for long-term memory storage and learning. Human, mouse, rat, and pig BDNF are cross-reactive.

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      • Properties
        • Protein Name
          Abrineurin
          Source
          Genetically modified E.coli
          Type
          Recombinant Proteins
          Purification
          Reducing and Non-Reducing SDS PAGE at >= 95%
          Formulation
          Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)
          Sterile water at 0.1 mg/mL
          Storage
          Store at -20°C
          Endotoxin
          Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test.
          Activity
          Biological Activity was determined by C6 cell proliferation at <=2 ug/mL; >= 5.0 x 10^2 units/mg (typical ED50 is < 1 ug/mL). Centrifuge vial before opening, Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws. Upon reconstitution, a small amount of visible precipitate can be expected. A 10% overfill has been added to the total material vialed to compensate for this loss.

          More Information

          UniProt
          Gene ID
          627

          * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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