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Target Information
Target NameAtaxin-2; Spinocerebellar Ataxia Type 2 Protein; Trinucleotide Repeat-Containing Gene 13 ProteinDatabase LinksUniprot ID: VTDB_HUMAN ; Gene ID: 6311About TargetTissue Specificity: Expressed in the brain, heart, liver, skeletal muscle, pancreas and placenta. Isoform 1 is predominant in the brain and spinal cord. Isoform 4 is more abundant in the cerebellum. In the brain, broadly expressed in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus.
Function: Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane.
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