Human BAG3 (Bcl2 Associated Athanogene 3) ELISA Kit

Bag Family Molecular Chaperone Regulator 3; Bag-3; Bcl-2-Associated Athanogene 3; Bcl-2-Binding Protein Bis; Docking Protein Cair-1

Uniprot ID: GCSP_HUMAN ; Reactome: R-HSA-3371453 ; Gene ID: 9531

Function: Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Has anti-apoptotic activity. Plays a role in the HSF1 nucleocytoplasmic transport.