Human ASGR2 (Asialoglycoprotein Receptor 2) CLIA Kit

Asialoglycoprotein Receptor 2; Asgp-R 2; Asgpr 2; C-Type Lectin Domain Family 4 Member H2; Hepatic Lectin H2; Hl-2

Uniprot ID: NEUM_HUMAN ; Reactome: R-HSA-446203 ; Gene ID: 433

Tissue Specificity: Expressed exclusively in hepatic parenchymal cells.

Function: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.