Human ASGR1 (Asialoglycoprotein Receptor 1) CLIA Kit

Asialoglycoprotein Receptor 1; Asgp-R 1; Asgpr 1; C-Type Lectin Domain Family 4 Member H1; Hepatic Lectin H1; Hl-1

Uniprot ID: GALR1_HUMAN ; Reactome: R-HSA-446203 ; Gene ID: 432

Tissue Specificity: Expressed exclusively in hepatic parenchymal cells.

Function: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.