Human ADM (Adrenomedullin) CLIA Kit

Pro-Adrenomedullin Cleaved Into - Adrenomedullin; Am - Proadrenomedullin N-20 Terminal Peptide; Proam N-Terminal 20 Peptide; Pamp; Proam-N20

Uniprot ID: ODP2_HUMAN ; Reactome: R-HSA-418555 ; Gene ID: 133

Tissue Specificity: Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues.

Function: AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.