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Overview
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This ADAMTS4 CLIA Kit is a highly sensitive in-vitro chemiluminescent immunoassay for the measurement of trace amounts of analytes.
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Target Information
Target NameA Disintegrin And Metalloproteinase With Thrombospondin Motifs 4; Adam-Ts 4; Adam-Ts4; Adamts-4; Admp-1; Aggrecanase-1Database LinksUniprot ID: PGS2_HUMAN ; Reactome: R-HSA-1474228 ; Gene ID: 9507About TargetTissue Specificity: Expressed in brain, lung and heart. Expressed at very low level in placenta and skeletal muscles. Isoform 2: Detected in osteoarthritic synovium.
Function: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
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