Human 5HT2B-Strep full length protein-synthetic nanodisc

Human 5HT2B-Strep full length protein-synthetic nanodisc

Catalog Number:
P001561600DIM
Mfr. No.:
FLP120167
Price:
$911
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      • Overview

        • Target: 5HT2B
          Tag: C-Flag&Strep Tag
          Synonyms: 5-HT(2B), 5-HT-2B, 5-HT2B
          Protein Families: Transmembrane, Druggable Genome
          Protein Pathways: GPCRDB Class A Rhodopsin-like, Monoamine GPCRs

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          Background

          This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]

      • Properties
        • Type
          Synthetic Nanodiscs
          Conjugate
          Unconjugated
          Formulation
          Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments.
          Storage
          Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
          Molecular Weight
          The human full length 5HT2B-Strep protein has a MW of 54.3 kDa
          Expression system
          HEK293

          More Information

          UniProt
          P41595

          * For research use only.

    MSDS

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