Hmgb2 Knock Out Mouse Embryonic Fibroblasts

- Overview
  - The knockout cells are generated by the laboratory of Prof. Marco E. Bianchi for research purposes. San Raffaele Research Institute remains the owner of the intellectual property associated to these cells, and requires anyone interested in acquiring them to sign an MTA.
    The cells are shipped in dry ice. Since they are living biological material, they will be checked at customs. Therefore, communication between us and the buyer is required to optimize the delivery.
    
    These Hmgb2 / and Hmgb2-/- MEFs were obtained from sib embryos from crosses of Hmgb2 heterozygotes (Ronfani et al., Development 128: 1265-73) on a pure BALB/c genetic background (>10 backcrosses, unpublished), and grown according to the 3T3 protocol, which prescribes splitting 1:3 the growing cells every 3 days for 3 months.
    
    We suggest to split the cells, by trypsinization, when they reach 80% confluence.
    
    Please contact us at for specific academic pricing.
- Properties
  - Categories
    
    Cells
    
    * This product is intended for research only, and cannot be used on humans.
- Reference
  - Ionizing radiation induces vascular smooth muscle cell senescence through activating NF-κB/CTCF/p16 pathway
    HMGB2 Deficiency Mitigates Abdominal Aortic Aneurysm by Suppressing Ang-II-Caused Ferroptosis and Inflammation via NF- κβ Pathway
    Identification of aging-related genes in diagnosing osteoarthritis via integrating bioinformatics analysis and machine learning
    Transcription factors-related molecular subtypes and risk prognostic model: exploring the immunogenicity landscape and potential drug targets in hepatocellular carcinoma
    Exploring HMGB2 in hepatocellular carcinoma: charting new paths for diagnostic and therapeutic innovations
    Blocking the E2F transcription factor 1/high-mobility group box 2 pathway enhances the intervention effects of α-santalol on the malignant behaviors of liver cancer cells
    Comparative Transcriptomic Analysis of Cerebellar Astrocytes across Developmental Stages and Brain Regions
    Neurogenic to Gliogenic Fate Transition Perturbed by Loss of HMGB2
    PfHMGB2 has a role in malaria parasite mosquito infection
    Duck HMGB2 Mediates Signaling Pathways in the Innate Immunity of Hosts Against Viral Infections
    The elucidation of the anti-inflammatory mechanism of EMO in rheumatoid arthritis through an integrative approach combining bioinformatics and experimental verification
    High-mobility group box-1 peptide ameliorates bronchopulmonary dysplasia by suppressing inflammation and fibrosis in a mouse model
    MIR-107/HMGB1/FGF-2 axis responds to excessive mechanical stretch to promote rapid repair of vascular endothelial cells
    FSHD muscle shows perturbation in fibroadipogenic progenitor cells, mitochondrial function and alternative splicing independently of inflammation
    A Review of Proposed Mechanisms in Rheumatoid Arthritis and Therapeutic Strategies for the Disease
    Blockade of HMGB1 Reduces Inflammation and Pruritus in Atopic Dermatitis by Inhibiting Skin Fibroblasts Activation
    NOD2 attenuates osteoarthritis via reprogramming the activation of synovial macrophages
    The elucidation of the anti-inflammatory mechanism of EMO in rheumatoid arthritis through an integrative approach combining bioinformatics and experimental verification
    Nucleotide-Binding Oligomerization Domain-Like Receptor 3 Deficiency Attenuated Isoproterenol-Induced Cardiac Fibrosis via Reactive Oxygen Species/High Mobility Group Box 1 Protein Axis
    Extracellular HMGB1 Contributes to the Chronic Cardiac Allograft Vasculopathy/Fibrosis by Modulating TGF-β1 Signaling