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Overview
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HIV-1 p24 is carried in the blood of people infected with HIV.It has been shown that a p24
antigen level of >5 pg/ml is predictive of disease progression with an accuracy comparable
to that of CD4 lymphocyte count (<350 lymphocytes/mm3) and HIV-1 RNA viral load >30,000
copies/ml, which are cut-offs used in guidelines for the initiation of antiretroviral therapy.Viral capsid protein p24 plays important roles in HIV pathogenesis. Peptides and small
molecule inhibitors targeting p24 have shown to inhibit virus replication in treated cells.
The p24 capsid protein plays important roles in both early and late stages of HIV-1 replication
cycle. During the virus particle assembly, capsid domains interact with Gag polyprotein that
undergoes proteolytic cleavage and transforms the immature particles to mature virions.Please contact us at for specific academic pricing.
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