Name: GSK837149A
Price: 318.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    GSK837149A is a selective and reversible inhibitor of fatty acid synthase (FAS) [1].
    Fatty acids are essential for all the living cells and have a diversity of biological functions. Fatty acids are fundamental aliphatic acids served as energy production and storage, cellular structure and as intermediates in the biosynthesis of hormones and other biologically important molecules. In cells, fatty acids provide structural integrity to cellular membranes and cell walls. Fatty acids have been also involved in the transmission of cellular signals and can be used to modify proteins during post-translational processing. Fatty acid synthase has been involved in catalyzing the formation of long-chain fatty acids from acetyl-CoA and malonyl-CoA in the presence of NADPH [1].
    GSK837149A inhibited FAS in a reversible manner, with a Ki value of ~30 nm. GSK837149A possibly bound to the enzyme–ketoacyl-ACP complex [1]. GSK837149A selectively and reversibly inhibited the activity of FAS with the pIC50 of 7.8 [1]. GSK837149A functioned by inhibiting the β-ketoacyl reductase activity of FAS [1].
- Properties
  - Alternative Name
    
    4,4'-(carbonyldiimino)bis[N-(4-methyl-2-pyrimidinyl)-benzenesulfonamide
    
    CAS Number
    
    13616-29-0
    
    Molecular Formula
    
    C23H22N8O5S2
    
    Molecular Weight
    
    554.6
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    Purity ≥ 95.00%
    
    Solubility
    
    ≤5mg/ml in DMSO;5mg/ml in dimethyl formamide
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

GSK837149A

GSK837149A

Background

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