GSK2881078

GSK2881078

Catalog Number:
FC01366493APE
Mfr. No.:
APE-C4768
Price:
$365
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      • Overview
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          Background

          GSK2881078 is a potent and selective androgen receptor modulator (SARM) [1]. Steroidal nuclear receptor (NR) ligands play important roles in the health of both men and women. Dihydrotestosterone (DHT) and testosterone (T) are endogenous steroidal ligands for the androgen receptor (AR) that play a role in every tissue type found in the mammalian body. During the development of the fetus, androgens play an important role in sexual differentiation and development of male sexual organs. SARMs are small molecule pharmacotherapeutics that have the potential to afford the important benefits of androgen therapy without the undesired side-effects [1]. GSK2881078 is a potent and selective androgen receptor modulator (SARM) that is being evaluated for effects on muscle growth and strength in subjects with muscle wasting to improve their physical function. GSK2881078 is currently in phase I clinical trials [1].

          Reference:[1]. https://newdrugapprovals.org/2016/06/14/gsk-2881078/

      • Properties
        • Categories
          selective androgen receptor modulator (SARM)
          Alternative Name
          1-[(1R)-1-methyl-2-(methylsulfonyl)ethyl]-4-(trifluoromethyl)-1H-indole-5-carbonitrile
          CAS Number
          1539314-06-1
          Molecular Formula
          C14H13F3N2O2S
          Molecular Weight
          330.3
          Appearance
          A crystalline solid
          Purity
          98.00%
          Solubility
          ≤20mg/ml in ethanol;25mg/ml in DMSO;25mg/ml in dimethyl formamide
          Storage
          Store at -20°C
          SMILES
          CS(C[[email protected]@H](C)N1C2=CC=C(C#N)C(C(F)(F)F)=C2C=C1)(=O)=O

          * For Research Use Only

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