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Overview
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Glycoprotein 2 (GP2) is a GPI-anchored protein abundantly produced by the pancreas, but is also expressed on intestinal membranous cells (M-cells), where it serves as a receptor for the phagocytosis of FimH+ Gram-negative bacteria to induce the mucosal immune response. Some results suggest an additional immunosuppressive and anti-inflammatory function of GP2.
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