Name: GM3-Ganglioside ammonium
Price: Inquiry

- Overview
  - Ganglioside GM3 (ammonium salt) has a core disaccharide structure (Galβ1,4Glc) with sialic acid linked a2,3 to the galactose residue and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). Ganglioside GM3 is strongly associated with human tumors, such as, lung, brain and melanomas where it is over expressed. It is seen as a possible tumor-associated carbohydrate antigen for cancer immunotherapy (Changping, 2019). GM3 ganlioside is implicated in various other diseases involving chronic inflammation, such as, insulin resistance, leptin resistance, T-cell function and immune disorders (e.g. allergic asthma). GM3 ganglioside has also been shown to play an essential role in murine and human auditory systems, and a common pathological feature of GM3S deficiency is deafness (Inokuchi, 2018).
    
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- Properties
  - Categories
    
    Ganglioside Oligosaccharides and Gangliosides
    
    CAS Number
    
    54827-14-4
    
    Molecular Formula
    
    C59H111N3O21xNH4
    
    Molecular Weight
    
    1,198.52 g/mol
    
    Note
    
    There is no hazardous surcharge associated with this product.
    There is no special packaging charge associated with this product.
    
    * For research use only. Not for human or veterinary use
- Reference
  - Ledeen et al (2009), Neurobiology Meets Glycosciences, In: The Sugar Code (Ed: Gabius H. J) pp 495-516, Wiley-VCH, Weinheim
    Changping et al (2019) Ganglioside GM3 and Its Role in Cancer, Current Medicinal Chemistry, 26(16), 2933-2947
    Inokuchi et al (2018) Chapter Five - Biology of GM3 Ganglioside,
    Schnaar et al (2018) Progress in Molecular Biology and Translational Science, Academic Press, 156, 151-195,

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