GDC 0941

Name: GDC 0941
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Catalog Number:

L002236037BIO

Mfr. No.:

FI32904

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Properties

Categories

Enzyme Modulators

Alternative Name

2-(1H-Indazol-4-yl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidine; Pictilisib

CAS Number

957054-30-7

Molecular Formula

C23H27N7O3S2

Molecular Weight

513.64 g/mol

MDL Number

MFCD11616196

Note

There is no hazardous surcharge associated with this product.
There is no special packaging charge associated with this product.

* For research use only. Not for human or veterinary use

Reference

Folkes et al (2008). The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer. Journal of Medicinal Chemistry, 51(18):5522-32.
Raynaud et al (2009). Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941. Molecular Cancer Therapeutics, 8(7):1725-38.
Hoeflich et al (2012). Intermittent administration of MEK inhibitor GDC-0973 plus PI3K inhibitor GDC-0941 triggers robust apoptosis and tumor growth inhibition. Cancer Research, 72(1):210-9.

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