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Overview
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GAGE2D Human Recombinant produced in E. Coli is a single, non-glycosylated polypeptide chain containing 139 amino acids (1-116 a.a) and having a molecular mass of 15.2kDa (Molecular size on SDS-PAGE will appear higher). GAGE2D is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. GAGE2D is a member of the GAGE family, which organized in clusteredrepeats. In addition, they have a high degree of predicted sequence identity, butdiffer by scattered single nucleotide substitution. The first GAGE nomenclature was based onidentified mRNA sequences; however the high identity of the GAGE members made it impossible toseparate products of paralogous genes from polymorph products. Moreover GAGE2Dis not expressed in normal tissues, except in testis; however it is expressedby a large proportion of tumors of various histological origins.
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- Properties
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Overview