Name: FPS-ZM1
Price: 180.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Ki: 25 nMFPS-ZM1 is a RAGE Inhibitor.The receptor for advanced glycation end products (RAGE) belongs to the immunoglobulin superfamily. RAGE has an extracellular V domain binding multiple ligands. The ligand-RAGE interactions result in sustained cellular perturbation in chronic diseases including diabetes, inflammation, as well as AD.In vitro: FPS-ZM1 was identified as a high-affinity inhibitor of the receptor for advanced glycation end products. FPS-ZM1 could block the binding of amyloid β (Aβ) protein to RAGE and inhibit Aβ40- and Aβ42-induced cellular stress in RAGE-expressing cells [1].In vivo: Animal study found that FPS-ZM1 was nontoxic to mice and readily crossed the blood-brain barrier (BBB). In aged APPsw/0 mice overexpressing human Aβ-precursor protein, FPS-ZM1 could inhibit RAGE-mediated influx of circulating Aβ40 and Aβ42 into the brain. FPS-ZM1 bound exclusively to RAGE In brain, which inhibited β-secretase activity and Aβ production and suppressed microglia activation and the neuroinflammatory response. Moreover, the blockade of RAGE actions at the BBB and in the brain could reduce Aβ40 and Aβ42 levels in brain in aged APPsw/0 mice [1].Clinical trial: So far, no clinical study has been conducted.
- Properties
  - Alternative Name
    
    RAGE Antagonist; 4-chloro-N-cyclohexyl-N-(phenylmethyl)-benzamide
    
    CAS Number
    
    945714-67-0
    
    Molecular Formula
    
    C20H22ClNO
    
    Molecular Weight
    
    327.9
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in H2O; ≥14.43 mg/mL in EtOH; ≥28.6 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

FPS-ZM1

FPS-ZM1

Background

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