Fosinopril sodium

- Overview
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    Background
    
    Fosinopril sodium is an effective inhibitor of angiotensin-converting enzyme (ACE) with IC50 value of 9nM [1].Fosinopril is a third type ACE inhibitor with a phosphinic acid. It binds to the active site of ACE via targeting the zinc ions with its phosphinic acid moiety. Fosinopril is an orally active prodrug which is hydrolysed and converted to its active diacid fosinoprilat after oral administration. The absorption of fosinopril ranges between 18 and 41 %. Antacids can affect the absorption of fosinopril and cause a decrease in its bioavailability by increasing the gastric pH. The pharmacokinetics assay shows fosinopril is hydrolysed completely into fosinoprilat after absorption. And fosinoprilat is slowly eliminated by renal and hepatic clearance. Fosinopril is proved to produce sustained blood pressure reduction through improving systemic and renal haemodynamics and reducing left ventricular mass [1].
    
    [1] Shionoiri H, Naruse M, Minamisawa K, Ueda S, Himeno H, Hiroto S, Takasaki I. Fosinopril. Clinical pharmacokinetics and clinical potential. Clin Pharmacokinet. 1997 Jun;32(6):460-80.
- Properties
  - Alternative Name
    
    sodium;(2S,4S)-4-cyclohexyl-1-[2-[(2-methyl-1-propanoyloxypropoxy)-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylate
    
    CAS Number
    
    88889-14-9
    
    Molecular Formula
    
    C30H45NO7P·Na
    
    Molecular Weight
    
    585.64
    
    Purity
    
    98.00%
    
    Solubility
    
    Soluble in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

Fosinopril sodium

Background

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