Fmoc-N-amido-dPEG®₁₂-NHS ester

Fmoc-N-amido-dPEG®12-NHS ester, product number 10996, is one of Quanta BioDesign's peptide synthesis products. This product is pre-activated with an N-hydroxysuccinimide (NHS) ester for conjugation to free amines. The dPEG®12 spacer allows the introduction of a medium-length, hydrophilic spacer into, for example, a peptide chain.

PEGylation with Quanta BioDesign's dPEG® Products
PEGylation is the covalent addition of polyethylene glycol (PEG) to a compound or surface. PEGylated compounds include proteins, peptides, dyes or other labels, and small molecule drugs. Peptide synthesis frequently employs PEGylation to enhance a peptide's water solubility. Moreover, peptide PEGylation prolongs the in vivo circulation of peptide conjugates by both increasing the peptide's hydrodynamic volume and protecting the peptide from proteolysis. Additionally, PEGylation reduces or eliminates the antigenicity of the conjugated peptide.

However, traditional PEGs are dispersed polymers (Đ > 1.00) consisting of multiple chain lengths with different molecular weights. The stated molecular weight for a conventional PEG indicates an average of the distribution of chain lengths and molecular weights.

Oursingle molecular weight PEG products (known as "discrete PEG" and sold under the dPEG® trademark) provide all of the benefits of traditional, dispersed PEG without the analytical headache that comes from having an intractable mixture of conjugates, each with different PEG chain lengths.

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