Fmoc-N-Lys-(dPEG®₁₂-biotin)-OH-(acid)

Fmoc-N-Lys-(dPEG®12-biotin)-OH, product number 10615, permits incorporation of a medium-length, biotinylated discrete PEG (dPEG®) into a peptide chain using standard Fmoc chemistry with Fmoc-protected lysine. The biotin-dPEG®12 moiety couples to the side chain of lysine. By design, this product permits incorporation of a water-soluble biotinylation reagent into a peptide chain.

Peptide PEGylation with dPEG® Products
PEGylation is the process of adding polyethylene glycol (PEG) to a peptide, protein, carbohydrate, or surface (for example, gold, silver, metal, silica, or plastic). PEG is amphiphilic, meaning that it is soluble in both water and many organic solvents. Thus, PEGylation imparts water solubility to molecules to which it is conjugated.

Peptide synthesis frequently uses PEGylation to improve the water solubility of hydrophobic peptides. Also, PEGylation protects peptides from enzymatic degradation in serum and increases the PEGylated peptide's hydrodynamic volume. A peptide's serum half-life increases with increasing hydrodynamic volume.

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