Fmoc-N-amido-dPEG®₄-NHS ester

Product number 10994, Fmoc-N-amido-dPEG®4-NHS ester, is one of Quanta BioDesign's peptide synthesis products. This product is activated with an N-hydroxysuccinimidyl (NHS) ester for direct conjugation to a peptide chain. The dPEG® spacer allows the introduction of a short, hydrophilic spacer into a peptide chain. The Fmoc protecting group on the N-terminus of the molecule cleaves easily with standard peptide chemistry.

PEGylation and dPEG® Products
PEGylation refers to the covalent addition of polyethylene glycol (PEG) to a compound or surface. PEGylated compounds include proteins, peptides, dyes or other labels, and small molecule drugs. Peptide synthesis frequently employs PEGylation to enhance the solubility of the peptide, because the amphiphilic character of PEG imparts tremendous water solubility to peptides. Moreover, peptide PEGylation prolongs in vivo circulation of peptide conjugates by both increasing the peptide's hydrodynamic volume and protecting the peptide from proteolysis. Additionally, PEGylation reduces or eliminates the antigenicity of the conjugated peptide.

However, traditional PEG products are dispersed polymers (Đ > 1.00). A traditional PEG consists of multiple chain lengths, each with different molecular weights. The stated molecular weight for a conventional PEG indicates an average of the distribution of chain lengths and molecular weights.

Oursingle molecular weight PEG products (known as "discrete PEG" and sold under the dPEG® trademark) provide all of the benefits of traditional, dispersed PEG without the analytical headache that comes from having an intractable mixture of conjugates, each with different PEG chain lengths.

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