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Fluvastatin

Fluvastatin

Catalog Number:
L002368651APE
Mfr. No.:
APE-A3419
Price:
$196
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      • Overview

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          Background

          Fluvastatin is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), the enzyme that catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Human hepatocellular carcinoma cell (HCC) studies indicate that Fluvastatin induces G2/M phase arrest. In the presence of Fluvastatin, HCC cells show a decrease of Bcl-2 and procaspase-9 expression, and an increase in Bax, cleaved caspase-3, and cytochrome c. Fluvastatin is antilipemic and is used to reduce plasma cholesterol levels and prevent cardiovascular disease.

      • Properties
        • Alternative Name
          Leschol; (E,3R,5S)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoic acid
          CAS Number
          93957-54-1
          Molecular Formula
          C24H26FNO4
          Molecular Weight
          411.47
          Appearance
          A solid
          Purity
          98.33%
          Solubility
          ≥20.57 mg/mL in DMSO; ≥32.53 mg/mL in H2O with gentle warming; ≥42.2 mg/mL in EtOH with gentle warming
          Storage
          Store at -20°C

          * For Research Use Only

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