Fludarabine Phosphate (Fludara)

Name: Fludarabine Phosphate (Fludara)
Price: 180.00 USD

Catalog Number:

L002369463APE

Mfr. No.:

APE-A8317

Price:

$180

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- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Fludarabine phosphate is a STAT-1 activation inhibitor and a DNA synthesis inhibitor. Fludarabine phosphate is the phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth.
- Properties
  - Alternative Name
    
    Fludura; [(2R,3S,4S,5R)-5-(6-amino-2-fluoropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
    
    CAS Number
    
    75607-67-9
    
    Molecular Formula
    
    C10H13FN5O7P
    
    Molecular Weight
    
    365.21
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in EtOH; ≥17.6 mg/mL in DMSO; ≥6.7 mg/mL in H2O with gentle warming and ultrasonic
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    C1=NC2=C(N1C3C(C(C(O3)COP(=O)(O)O)O)O)N=C(N=C2N)F
    
    * For Research Use Only
- Reference
  - 1. Wenli Yuan, Deyao Deng, et al. "IFNγ/PD-L1 Signaling Improves the Responsiveness of Anti-PD-1 Therapy in Colorectal Cancer: An in vitro Study." Onco Targets Ther. 2021 May 7;14:3051-3062. PMID:33994797
    2. Diqi Yang, Ai Liu, et al. "BCL2L15 Depletion Inhibits Endometrial Receptivity via the STAT1 Signaling Pathway." Genes (Basel). 2020 Jul 17;11(7):816. PMID:32708974
    3. Deng R, Zhang P, et al. "HDAC is indispensable for IFN-γ-induced B7-H1 expression in gastric cancer." Clin Epigenetics. 2018 Dec 11;10(1):153. PMID:30537988
    4. Yuan W, Deng D,et al."Hyperresponsiveness to interferon gamma exposure as a response mechanism to anti-PD-1 therapy in microsatellite instability colorectal cancer." Cancer Immunol Immunother. 2018 Nov 7. PMID:30406373

Fludarabine Phosphate (Fludara)

Fludarabine Phosphate (Fludara)

Background

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