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Overview
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Background
Finasteride acetate(MK-906,Proscar and Propecia) is a specific inhibitor of 5α-reductase and a drug of synthetic used in the benign prostatic hyperplasia (BPH) and the male pattern baldness (MPB) [1].In vivo, Finasteride acetate (MK-906, Proscar and Propecia) has been reported to significant reduce the concentration of DHT in prostatic tissue without side effects in pharmacologic experiments in rats and dogs. In addition, Finasteride acetate has shown the inhibition of 5α-reductase activity resulted in significant inhibition of DHT levels. Finasteride acetate has also shown the effect on reducing prostate volume in clinical experiments [1]. Finasteride acetate has been revealed to have the function to inhibit glucuronyl transferase in vitro test using rat prostate tissue [2].
[1] Stoner E.The clinical development of a 5 alpha-reductase inhibitor, finasteride. J Steroid Biochem Mol Biol. 1990 Nov 20;37(3):375-8.
[2] Rittmaster RS1, Stoner E, Thompson DL, Nance D, Lasseter KC.Effect of MK-906, a specific 5 alpha-reductase inhibitor, on serum androgens and androgen conjugates in normal men. J Androl. 1989 Jul-Aug;10(4):259-62.
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