Name: Tandospirone
Price: 268.00 USD

- Overview
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    Background
    
    Tandospirone (SM-3997; sediel ) is an anxiolytic and antidepressant [1]. Tandospirone has been reported to produce a significant increase in number of shocks at doses of 5 and 10mg/kg, i .p. or 20 and 40 mg/kg, p.o.. 10mg/kg, i.p. of Tandospirone has been revealed to produce a significant increase in the number of shocks following the repeated treatment for 5 or 10 days. In addition, has been noted to impair rota-rod performance at relatively high doses with ED50 values of 207 mg/kg, p.o. and 300mg/kg, p.o. in mice and rats, respectively. Besides, Tandospirone has been evaluated to enhance the duration of the hexobarbital-induced anesthesia with an ED50 value of 212mg/kg, p.o. [1].
    
    [1] Shimizu H1, Hirose A, Tatsuno T, Nakamura M, Katsube J. Pharmacological properties of SM-3997: a new anxioselective anxiolytic candidate. Jpn J Pharmacol. 1987 Dec; 45(4):493-500.
- Properties
  - Categories
    
    Anxiolytic and antidepressant reagent
    
    Alternative Name
    
    (3aR,4S,7R,7aS)-2-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione
    
    CAS Number
    
    87760-53-0
    
    Molecular Formula
    
    C21H29N5O2
    
    Molecular Weight
    
    383.49
    
    Appearance
    
    A solid
    
    Purity
    
    99.23%
    
    Solubility
    
    ≥38.3 mg/mL in DMSO; insoluble in H2O; ≥12.8 mg/mL in EtOH
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    O=C([[email protected]@]1([H])[[email protected]@](C([H])([H])C2([H])[H])([H])C([H])([H])[[email protected]@]2([H])[[email protected]]13[H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])N(C5=NC([H])=C([H])C([H])=N5)C([H])([H])C4([H])[H])C3=O
    
    * For Research Use Only