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Overview
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6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide (racemic)
EX-427 is a selective Sirt1 inhibitor (IC50=98 nM). Does not inhibit other HDACs or Sirt family members. Increases p53 acetylation following DNA damage. Causes cell cycle arrest at G1. Inhibits differentiation and facilitates expansion of hematopoietic progenitor cells. An extremely useful tool for determining the involvement of Sirt1 in cellular physiology. Cell permeable.Please contact us at for specific academic pricing.
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