Esomeprazole Magnesium trihydrate

- Overview
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    Background
    
    Esomeprazole Magnesium (Nexium) is a proton pump inhibitor to reduce gastric acid secretion. The stability of Esomeprazole Magnesium is a function of pH; it rapidly degrades in acidic media, but it has acceptable stability under alkaline conditions. At pH 6.8 (buffer), the half-life of the magnesium salt is about 19 hours at 25°C and about 8 hours at 37°C. Recent randomized controlled trials in patients who are at moderately increased risk of ulcers have shown that the proton pump inhibitor Esomeprazole (the S-isomer of racemic omeprazole) reduces the gastroduodenal ulcer incidence by approximately 70-85% and the gastrointestinal bleeding risk by as much as 90%.
- Properties
  - Alternative Name
    
    (S)-Omeprazole magnesium trihydrate; magnesium;5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]benzimidazol-1-ide;trihydrate
    
    CAS Number
    
    217087-09-7
    
    Molecular Formula
    
    C34H42MgN6O9S2
    
    Molecular Weight
    
    767.17
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥110.6 mg/mL in DMSO; ≥39 mg/mL in EtOH; insoluble in H2O
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only