Etifoxine hydrochloride

- Overview
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    Background
    
    Etifoxine is potentiator of GABAA receptor function in cultured neurons. Etifoxine preferentially acts on β2 or β3 subunit-containing GABAA receptors. Etifoxine exhibits anxiolytic activity in rodents and humans with no sedative, myorelaxant or mnesic side effects. Etifoxine acts as a ligand of the translocator protein (TSPO); promotes axonal regeneration.
- Properties
  - Categories
    
    GABAA receptor potentiator
    
    Alternative Name
    
    Stresam;HOE 36-801; 6-chloro-N-ethyl-4-methyl-4-phenyl-3,1-benzoxazin-2-amine;hydrochloride
    
    CAS Number
    
    56776-32-0
    
    Molecular Formula
    
    C17H18Cl2N2O
    
    Molecular Weight
    
    337.24
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥33.7 mg/mL in DMSO with gentle warming; ≥15.49 mg/mL in H2O with gentle warming; ≥48.1 mg/mL in EtOH with gentle warming
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CCNC1=NC2=C(C=C(C=C2)Cl)C(O1)(C)C3=CC=CC=C3.Cl
    
    * For Research Use Only