Name: Emodepside
Price: 401.00 USD

- Overview
  - Emodepside is an anthelmintic, belonging to the cyclooctadepsipeptides class. It is effective against gastrointestinal nematodes. The starting material of Emodepside is a natural metabolite of the fungus Mycelia sterilia, which inhabits the leaves of Camellia japo.
    
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    Background
    
    Emodepside binds to G-protein coupled receptors called latrophilins. Following binding, the Gq protein activates the signaling molecule phospholipase C-β a protein that modulates regulatory pathways of vesicle release. The process involves Slo-1 (potassium channel). An unidentified transmitter interferes with signaling at the neuromuscular junction and affects nematode movement, feeding, and reproduction.
    Researchers at Bayer in Berlin, Germany found that Emodepside directly opens a Slo-1 channel. Slo-1 deficiant C. elegans are completely resistant to Emodepside. Molecular analyses identified full length Slo-1 cDNAs of a variety of species of parasitic nemotodes, and found substantial differences among channel properties (Kulke et al, 2014).
- Properties
  - CAS Number
    
    155030-63-0
    
    Molecular Formula
    
    C₆₀H₉₀N₆O₁₄
    
    Molecular Weight
    
    1119.39
    
    Appearance
    
    White to pale yellow crystal powder
    
    Solubility
    
    Soluble in DMSO.
    
    Other Properties
    
    Source: Semi-synthetic
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Broad-spectrum anthelmintic activity including nematodes such as Ascaris sum and C. elegans.