DOTA-tris(acid)-amido-dPEG®₂₃-Maleimide

DOTA-tris(acid)-amido-dPEG®23-maleimide, product number 11171, links a thiol-reactive maleimide group with the macrocyclic, bifunctional chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) through a medium-length, single molecular weight, discrete PEG (dPEG®) linker. The DOTA moiety is designed to chelate trivalent yttrium and trivalent elements in the lanthanide series. The maleimide group chemoselectively reacts with thiols at pH 6.5 – 7.5 in a click chemistry type of reaction.

Traditional PEG is a dispersed (Đ > 1) polymer. By contrast, Quanta BioDesign produces only single molecular weight (that is, discrete) PEG products (that is, Đ = 1). Our smaller dPEG® products avoid problems associated with large PEGs. The discrete character of our products simplifies analysis of the dPEG® product and of conjugates formed with dPEG® products.

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