DNase I, GMP Grade (2U/μl)

- Overview
  - DNase I (Deoxyribonuclease I) was initially isolated from bovine pancreas. It can randomly degrade single stranded or double stranded DNA with equal efficiency, generating oligonucleotides with 5’-P. The bioactivity of DNase I is highly dependent on Ca2+, Mg2+ or Mn2+. In the presence of Mg2+, DNase randomly cuts dsDNA; in the presence of Mg2+, DNase cleaves both strands of dsDNA at approximately the same site, resulting in a blunt end or a sticky end with 1 or 2 protruding nucleotides.
    DNase I is GMP Grade produced in Pichia pastoris. Our manufacturing processes are strictly controlled to ensure the end products free from host protein or nucleic acid contaminations and other impurities following the Pharmaceutical Manufacturing Guidelines. We guarantee the manufacturing and quality control comply with GMP regulation for tracking each and every step of the manufacturing process, including raw material sourcing.
    This product has completed the DMF record of FDA and passed the HALAL certification.
    
    Please contact us at for specific academic pricing.
    
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    FDA DMF Filed Enzymes
- Properties
  - Storage
    
    At -20±5 °C.
    
    Endotoxin
    
    ＜5EU/ml
    
    Activity
    
    1.8KU/ml-2.2KU/ml (Activity Definition: One unit is defined as the amount of enzyme required to completely degrading 1μg DNA of BR322 plasmid in 10minute at 37°C in a 50µl reaction volume.)
    
    * For Research or Manufacturing Use Only, Not for Use in Diagnostic or Therapeutic Procedures.
- Reference
  - Intratumoral Delivered Novel Circular mRNA Encoding Cytokines for Immune Modulation and Cancer Therapy
    An mRNA-based rabies vaccine induces strong protective immune responses in mice and dogs

Datasheet

DNase I, GMP Grade (2U/μl)

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