DL-threo-PPMP (hydrochloride)

- Overview
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    Background
    
    DL-threo-PPMP (hydrochloride) is an inhibitor of glucosylceramide synthase [1].Glucosylceramide synthase (GCS) is a pervasive enzyme inherent to intracellular ceramide metabolism. The enzyme has been involved in catalyzing the transfer of glucose to ceramide, which is the principle committed step in glycolipid biosynthesis. GCS has been involved in the cytotoxic response of cancer cells to chemotherapy. Glucosylceramide synthase-based sphingolipids have been identified as important mediators of a variety of cellular functions, including proliferation, differentiation, development, and cell-cell recognition [2].DL-threo-PPMP was a ceramide analog. DL-threo-PPMP inhibited the activity of glucosylceramide synthase with an IC50 value between 2 and 20 μM. It has been used to study the role of glucosylceramide synthase in cell growth, apoptosis, and autophagy [1].
    
    [1] Lee L, Abe A, Shayman J A. Improved inhibitors of glucosylceramide synthase[J]. Journal of Biological Chemistry, 1999, 274(21): 14662-14669.
    [2] Bleicher R J, Cabot M C. Glucosylceramide synthase and apoptosis[J]. Biochimica et biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 2002, 1585(2): 172-178.
- Properties
  - Alternative Name
    
    DL-threo-1-Phenyl-2-palmitoylamino-3-morpholino-1-propanol; rel-N-[(1R,2R)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-hexadecanamide, monohydrochloride
    
    CAS Number
    
    139974-41-7
    
    Molecular Formula
    
    C29H50N2O3·HCl
    
    Molecular Weight
    
    511.2
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≤10mg/ml in ethanol;20mg/ml in DMSO;5mg/ml in dimethyl formamide
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

DL-threo-PPMP (hydrochloride)

Background

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