24α-methyl Cholesterol

24α-methyl Cholesterol

Catalog Number:
L002373271APE
Mfr. No.:
APE-C5751
Price:
$238
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      • Overview
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          Background

          24α-methyl Cholesterol is an agonist of liver X receptors (LXR).
          Liver X receptors (LXRs) are ligand-dependent transcription factors involved in the transcriptional control of lipid metabolism. LXRs function as nuclear cholesterol sensors that are activated by elevated intracellular cholesterol levels in multiple cell types. Activation of LXRs induces the expression of various genes involved in cholesterol absorption, transport, efflux, and excretion. In addition to their function in lipid metabolism, LXRs have also been found to modulate immune and inflammatory responses in macrophages. LXRα is highly expressed in the liver and at lower levels in the adrenal glands, adipose, intestine, lung, macrophages, and kidney, and LXRβ is ubiquitously expressed [2].
          24α-methyl Cholesterol was a phytosterol found in vegetables, nuts, fruits, and seeds that competitively inhibited the absorption of intestinal cholesterol and decreased the transcription of genes important for cholesterol metabolism [3]. 24α-methyl Cholesterol acted as an agonist at liver X receptors (LXR) and suppressed the proliferation of prostate and breast cancer cells [1].

          [1] Chuu C P, Kokontis J M, Hiipakka R A, et al. Modulation of liver X receptor signaling as novel therapy for prostate cancer[J]. Journal of biomedical science, 2007, 14(5): 543-553.
          [2] Zelcer N, Tontonoz P. Liver X receptors as integrators of metabolic and inflammatory signaling[J]. The Journal of clinical investigation, 2006, 116(3): 607-614.
          [3] Segura R, Javierre C, Lizarraga M A, et al. Other relevant components of nuts: phytosterols, folate and minerals[J]. British Journal of Nutrition, 2006, 96(S2): S36-S44.

      • Properties
        • Categories
          agonist at liver X receptors (LXR)
          Alternative Name
          Campesterol,NSC 224330; (3β,24R)-ergost-5-en-3-ol
          CAS Number
          474-62-4
          Molecular Formula
          C28H48O
          Molecular Weight
          400.7
          Appearance
          A crystalline solid
          Purity
          Purity ≥ 95.00%
          Solubility
          ≤0.25mg/ml in ethanol;1mg/ml in dimethyl formamide
          Storage
          Store at -20°C
          SMILES
          O[[email protected]](C1)CC[[email protected]@]2(C)C1=CC[[email protected]]3([H])[[email protected]]2([H])CC[[email protected]@]4(C)[[email protected]@]3([H])CC[[email protected]]4([H])[[email protected]](C)CC[[email protected]@H](C)C(C)C

          * For Research Use Only

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