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Overview
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DKK3 Human Recombinant produced in E. coli is a single polypeptide chain containing 353 amino acids (22-350) and having a molecular mass of 38.8 kDa. DKK3 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Dickkopf-related protein 3 (DKK3) belongs to the DKK protein family including Dkk-1, 2, 3 and -4. DKK3 is a 350 amino acid secreted glycoprotein which is comprised of an N-terminal signal peptide and 2 conserved cysteine-rich domains that are separated by a 12 amino acid linker region. DKK3 is involved in embryonic development through its inhibition of the WNT signaling pathway. DKK3 gene expression is decreased in a variety of cancer cell lines and it may act as a tumor suppressor gene.
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Overview