Name: Difloxacin HCl
Price: 180.00 USD

- Overview
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    Background
    
    Difloxacin HCl is a quinolone antimicrobial antibiotic [1]. Quinolone antibiotics target bacterial DNA gyrase which is required during DNA replication, subsequent DNA synthesis and ultimately cell division.In unselected cultured human neuroblastoma cells, difloxacin (50 microg/ml) increased sensitivity to the multidrug resistance-associated protein (MRP) substrates. Daunorubicin, doxorubicin, vincristine and potassium antimony tartrate is proportional to the level of MRP expression, which proves that difloxacin HCl reverse drug resistance in human neuroblastoma cells [1].Difloxacin HCl is a quinolone antimicrobial antibiotic and may reverse drug resistance in human neuroblastoma cells. Difloxacin HCl is commonly used in clinical in vitro antimicrobial susceptibility tests against gram-positive and gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients.
    
    [1]. Norris MD, Madafiglio J, Gilbert J, et al. Reversal of multidrug resistance-associated protein-mediated drug resistance in cultured human neuroblastoma cells by the quinolone antibiotic difloxacin. Med Pediatr Oncol, 2001, 36(1): 177-180.
- Properties
  - Categories
    
    quinolone antimicrobial antibiotic
    
    Alternative Name
    
    6-fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
    
    CAS Number
    
    91296-86-5
    
    Molecular Formula
    
    C21H19F2N3O3 HCl
    
    Molecular Weight
    
    435.86
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in EtOH; ≥7.36 mg/mL in H2O with ultrasonic; ≥9.15 mg/mL in DMSO with gentle warming
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CN1CCN(CC1)C2=C(C=C3C(=C2)N(C=C(C3=O)C(=O)O)C4=CC=C(C=C4)F)F
    
    * For Research Use Only
- Reference
  - 1. Kaisari S, Shomer P, et al. "Role of Polo-like kinase 1 in the regulation of the action of p31(comet) in the disassembly of mitotic checkpoint complexes." Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):11725-11730. PMID:31118282