Dianthus - Plate-based and Microfluidics-free Affinity Screening Platform

Dianthus is a plate-based and microfluidics-free affinity screening platform. Measurements are in solution and mass-independent - ideal for succeeding at demanding screening campaigns.

It's not surprising that the most important drug candidates and targets are super challenging when it comes to affinity screening. Immobilization-dependent SPR struggles with affinity screening campaigns for applications involving PROTAC binary and ternary complexes, fragment libraries, and intrinsically disordered proteins. These are precisely the applications where Dianthus excels.

Now with Spectral Shift and TRIC, two methods for measuring molecular interactions, Dianthus delivers high-quality data, has the sensitivity to detect more true binders, and requires less assay development to give you results from real-life samples.

· Measure the broadest range of affinities
Dianthus detects a wide range of binding affinities - picomolar to millimolar - so you catch very strong and weak binders.
· Characterize in solution, no immobilization required
Analyzing interactions in close-to-native conditions is ideal, especially when dealing with challenging targets. Never worry about negatively impacting your target's binding site or lacking control over equilibrium conditions, since measurements are done in solution.
· Consume small amounts of target and compounds
Every little bit counts. Saving on costly samples and library compounds means you can do more screening campaigns or projects.
· Automate your affinity screening campaigns
Get hours of uninterrupted and unattended operation with a format that's compatible with many automation solutions.

· Hit Identification
Finding true hits faster is the most important step in making your drug discovery workflow efficient. With Dianthus, you'll find hits quickly and move on to hit validation confidently, whether it's fragment-based or small molecule single-dose screening.
· Lead Validation
Spend less time sorting through the strong and weak binders. Dianthus generates easy-to-interpret affinity ranking tables and histograms to help you quickly decide on the right candidates and start lead optimization sooner.
· Lead Optimization
Once validation is complete, it's time to improve target specificity, selectivity, and potency. Use Dianthus to verify that binding affinities remain strong. This, combined with your ADME, toxicity, and PK/PD results, ensures you're developing the best drug candidates.

Measuring challenging interactions between various types of molecules at times requires a different approach. So having two different modalities in the same instrument helps you cover all the types of interactions you encounter. Dianthus comes with two biophysical modalities - Spectral Shift and Temperature Related Intensity Change (TRIC) - that help you measure the strength of your challenging molecular interactions.

Dianthus is a plate-based, microfluidics-free screening platform that easily integrates into any automated setup via gRPC framework. And with no regular maintenance, your projects don't get delayed due to downtime. Dianthus is ready whenever you need it - non-stop, 24/7.

Please contact us at for specific academic pricing.