Dianthus uHTS - Biophysical Affinity Measurement Platform

Biophysical methods have always had one weakness preventing them from being viable for primary screening - until now. Meet Dianthus uHTS, the only biophysical affinity measurement platform with the speed suitable for ultra-high-throughput screening.

Dianthus uHTS measures a 1536-well plate in only 8 minutes, and can be fully automated via an open gRPC framework. Data is delivered in whatever format you need, making it easy to integrate into your existing analysis workflow. No microfluidics minimizes maintenance, letting the instrument run 24/7. Dianthus uHTS does not get in the way, empowering scientists to move faster than ever before.

· Automate your affinity screening campaigns
Get hours of uninterrupted and unattended operation with a format that's compatible with any automation solution.
· Measure the broadest range of affinities
Dianthus uHTS detects a wide range of binding affinities - picomolar to millimolar - so you catch very strong and weak binders.
· Characterize in solution, no immobilization required
Analyzing interactions in close-to-native conditions is ideal, especially when dealing with challenging targets. Never worry about negatively impacting your target's binding site or lacking control over equilibrium conditions, since measurements are done in solution.
· Consume small amounts of target and compounds
Every little bit counts. Saving on costly samples and library compounds means you can do more screening campaigns or projects.

· Hit Identification
Finding true hits faster is the most important step in making your drug discovery workflow efficient. With Dianthus uHTS, you'll find hits quickly and move on to hit validation confidently, whether it's fragment-based or small molecule single-dose screening.
· Lead Validation
Spectral Shift has already been proven as a trusted method for lead validation. Dianthus uHTS lets you measure in 1536 or 384-well plates, giving you the flexibility you need to validate your hits regardless of library size.

Please contact us at for specific academic pricing.