Name: D1 peptide
Price: 275.00 USD

- Overview
  - Inhibits IL-13 binding to IL13R2.
    D1 is a peptide containing the 81-WKTIITKN-88 conserved sequence from the IL13R?2 binding site, the full sequence being that which interacts directly with IL-13 in site III. IL13R?2 is a cancer/testis-like tumour antigen that is overexpressed in various tumours, and in colorectal cancer, IL13R?2 expression is associated with late stage disease and lower overall survival. D1 blocks IL-13 binding to IL13R2 with near complete inhibition at 50g/ml, and in metastatic colorectal and glioblastoma cancer cells treated with IL-13, D1 peptide inhibits migration, invasion, and proliferation. In vivo, D1 peptide causes a modest increase in survival of mice innoculated with KM12SM colonic cancer cells preincubated with D1, but in contrast, the more stable D1 enantiomer consisting of all D amino acids, D-D1, causes a remarkable increase in survival in animal models, with 40% of mice surviving the experimental endpoint without metastatic lesions in liver. In glioblastoma xenografts, D-D1 peptide administration causes significant growth arrest accompanied by a regression in tumour size. Please contact us for the D-D1 peptide.
    
    Please contact us for availability.
    
    Please contact us at for specific academic pricing.
- Properties
  - Categories
    
    Peptides
    
    Alternative Name
    
    IL13Rα2 Peptide
    
    Molecular Formula
    
    C61H100N16O20
    
    Molecular Weight
    
    1376.73
    
    Appearance
    
    Freeze dried solid
    
    Purity
    
    >95% by HPLC
    
    Solubility
    
    Soluble in water
    
    Other Properties
    
    Sequence: H-Gly-Ser-Glu-Thr-Trp-Lys-Thr-Ile-Ile-Thr-Lys-Asn-OH,GSETWKTIITKN
    
    Storage
    
    Store dry, frozen and in the dark
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

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