[D-Phe6, β-Ala11, Phe13, Nle14]-Bombesin (6-14)

[D-Phe6, β-Ala11, Phe13, Nle14]-Bombesin (6-14)

Catalog Number:
P001269075SEV
Mfr. No.:
SBP0038
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      • Overview
        • [D-Phe6, β-Ala11, Phe13, Nle14]-Bombesin (6-14)
          MW: 1117.4
          H-D-Phe-Gln-Trp-Ala-Val-β-Ala-His-Phe-Nle-NH2
          This bombesin analogue has been found to be a high affinity ligand for the human orphan receptor, bombesin receptor subtype 3 (BRS-3). Neither bombesin itself nor any of its analogues that bind to other bombesin receptor subtypes exhibited significant affinity for BRS-3. Binding of this peptide to BRS-3 stimulates the formation of inositol phosphates. Guanosine 5'-(β,-imido)-triphosphate causes a change in receptor affinity, preventing binding of this ligand. These results indicate that for a member of the bombesin receptor family, BRS-3 has a unique pharmacological profile. The natural ligand for the BRS-3 receptor subtype is presumably either an undiscovered member of the bombesin family or an unrelated peptide
          Mantey, S.A. et al. (1997) J. Biol. Chem. 272, 26062.
          1mg
          5mg

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      • Properties
        • * For research use only.

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