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Overview
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[D-Phe6, β-Ala11, Phe13, Nle14]-Bombesin (6-14)
MW: 1117.4
H-D-Phe-Gln-Trp-Ala-Val-β-Ala-His-Phe-Nle-NH2
This bombesin analogue has been found to be a high affinity ligand for the human orphan receptor, bombesin receptor subtype 3 (BRS-3). Neither bombesin itself nor any of its analogues that bind to other bombesin receptor subtypes exhibited significant affinity for BRS-3. Binding of this peptide to BRS-3 stimulates the formation of inositol phosphates. Guanosine 5'-(β,-imido)-triphosphate causes a change in receptor affinity, preventing binding of this ligand. These results indicate that for a member of the bombesin receptor family, BRS-3 has a unique pharmacological profile. The natural ligand for the BRS-3 receptor subtype is presumably either an undiscovered member of the bombesin family or an unrelated peptide
Mantey, S.A. et al. (1997) J. Biol. Chem. 272, 26062.
1mg
5mgPlease contact us at for specific academic pricing.
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- Properties
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Overview