D-Cycloserine

- Overview
  - D-Cycloserine is an amino acid analog antibiotic. D-Cycloserine acts as a competitive inhibitor of D-alanine, an essential amino acid during peptidoglycan synthesis. It is a broad-spectrum antibiotic that can be used as a selective agent in several types of isolation media. D-cycloserine is soluble in water.
    
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    Background
    
    D-Cycloserine inhibits cell wall biosynthesis, specifically the D-Ala peptide bond formation. It competitively inhibits alanine racemase (which produces D-alanine) and D-alanine ligase, which joins the terminal 2 amino acid residues together. D-cycloserine is a ligand for the N-methyl-D-aspartate (NMDA) glycine receptor and has partial agonist characteristics, and has proven to have pharmacological activity in enhancing extinction memory.
- Properties
  - CAS Number
    
    68-41-7
    
    Molecular Formula
    
    C3H6N2O2
    
    Molecular Weight
    
    102.09
    
    Appearance
    
    White to pale white crystalline powder
    
    Solubility
    
    soluble in aqueous solution
    
    Other Properties
    
    Source: synthetic
    PH: 5.5-6.5
    Assay: (As Is): 900μg/mg
    Residue On Ignition: ≤0.5%
    Loss on Drying: ≤1.0%
    Optical Rotation: +108° to +114°
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: D-Cycloserine is a broad-spectrum antibiotic that can be used against the causal agent of tuberculosis (Mycobacterium tuberculosis).
    
    Microbiology Applications: D-Cycloserine can be used as a selective agent in several types of isolation media: Perfringens Agar - SFP and TSC selective supplements Clostridium difficile agar - Isolation of Clostridium difficile m-CP Medium - Membrane Clostridium perfringens Selective Supplement