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Overview
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The broad-spectrum antibacterial pexiganan with an additional N-terminal cysteine.
Cys-Pexiganan is the broad-spectrum antibacterial pexiganan with an additional N-terminal cysteine attached. Pexiganan is a 22-amino acid analog of the naturally occurring antimicrobial magainin2 , extracted from the skin of the African frog Xenopus laevis. Pexiganan exhibits in vitro broad-spectrum antibacterial activity against many clinical isolates of gram-positive and gram-negative, anaerobic and aerobic bacteria and is the best-studied AMP to date for therapeutic purposes. The addition of the N-terminal cysteine in Cys-pexiganan allows immobilization of pexiganan as a novel approach towards endowing material surfaces with bactericidal properties as well as attachment of fluorescent or biotin tags.
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Overview
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