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Overview
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Background
CD23 (FcεRII, BLAST-2), the low affinity IgE receptor, is a 45 kDa type II membrane glycoprotein expressed on eosinophils, follicular dendritic cells, Langerhans cells, mature B cells (mainly upon activation), EBV-transformed lymphoblasts, monocytes, and subpopulation of platelets. CD23 mediates IgE-dependent cytotoxicity by eosinophils and macrophages, and downregulates IgE secretion in response to high levels of IgE, involving release of pro-inflammatory cytokines.
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