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Cyclosporin A (Cyclosporine A)

Cyclosporin A (Cyclosporine A)

Catalog Number:
MG01441441INV
Mfr. No.:
V1858
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      • Overview

        • Cyclosporin A (Cyclosporine A; CsA) is a naturally occuring cyclic polypeptide immunosuppressive agent and a calcineurin inhibitor, which binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay. It is widely used in organ transplantation to prevent rejection. Cyclosporin A can also be used for rheumatoid arthritis, psoriasis, Crohn's disease, nephrotic syndrome, and in organ transplants to prevent rejection. Cyclosporin A is responsible for the opening of the MPTP (mitochondrial permeability transition pore). When tested with retinal ganglion cells, Cyclosporin A showed a high selectivity for the expression of cyclophilin D and prolonged the cells survival. In human First-Trimester Trophoblast Cells, Cyclosporin A treatment promoted cells growth and invasiveness by inhibiting Ca2+/Calcineurin/NFAT signal. Cyclosporin A treatment promoted the apoptosis of T-cell by upregulating Fas/FasL and caspase activities

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      • Properties
        • Categories
          Molecular Glues
          Molecular Weight
          1202.61
          Storage
          Powder: store in -20°C freezer for up to three years, store in 4°C freezer for up to two years
          In solvent: store in -80°C freezer for up to six months, store in -20°C freezer for up to two months

          * For research use only

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